The full training script for Enformer (Tensorflow Sonnet) on TPU clusters

Last update: Oct 19, 2022

Overview

Enformer TPU training script (wip)

The full training script for Enformer (Tensorflow Sonnet) on TPU clusters, in an effort to migrate the model to pytorch.

This was pieced together from the Deepmind Enformer repository, the colab training notebook, as well as Basenji sequence augmentation code

It accounts for:

distributed TPU training
distributed datasets
distributed validation
gradient clipping
cross replica batchnorms
dataset augmentation

Training takes about 3 days on v3-64

Todo

fix script for differences in sequence length in basenji training data, which is ~130k vs ~190k bp as in paper

Citations

@article {Avsec2021.04.07.438649,
    author  = {Avsec, {\v Z}iga and Agarwal, Vikram and Visentin, Daniel and Ledsam, Joseph R. and Grabska-Barwinska, Agnieszka and Taylor, Kyle R. and Assael, Yannis and Jumper, John and Kohli, Pushmeet and Kelley, David R.},
    title   = {Effective gene expression prediction from sequence by integrating long-range interactions},
    elocation-id = {2021.04.07.438649},
    year    = {2021},
    doi     = {10.1101/2021.04.07.438649},
    publisher = {Cold Spring Harbor Laboratory},
    URL     = {https://www.biorxiv.org/content/early/2021/04/08/2021.04.07.438649},
    eprint  = {https://www.biorxiv.org/content/early/2021/04/08/2021.04.07.438649.full.pdf},
    journal = {bioRxiv}
}

Comments

Gradient clipping: why not global norm ?

In the paper they say "We clipped gradients to a maximum global norm of 0.2." In https://github.com/lucidrains/enformer-tensorflow-sonnet-training-script/blob/6de9af047ecc1d8158afb8f12d128c6d504c5511/train.py#L1060 you choose to do simple clip_by_norm with a value of 1.0 I just wanted to ask the reasoning behind this choice, why did you not use tf.clip_by_global_norm instead ?

Just wanted to know if it's something you already tried and chose against as I struggle to train the model properly myself(using enformer_pytorch)

opened by sheetalgiri 0

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The full training script for Enformer (Tensorflow Sonnet) on TPU clusters

Related tags

Overview

Enformer TPU training script (wip)

Todo

Citations

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Gradient clipping: why not global norm ?

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